Create two transit gateways. Set up one AWS Site-to-Site VPN connection from the remote office to each transit gateway. Connect one VPC to the transit gateway. Configure route table propagation to the appropriate transit gateway based on the destination VPC IP range.

Set up one AWS Site-to-Site VPN connection from the remote office to each of the VPCs. Update the VPC route tables with static routes to the remote office resources.

Set up one AWS Site-to-Site VPN connection from the remote office to one of the VPCs. Set up VPC peering between the two VPCs. Update the VPC route tables with static routes to the remote office and peered resources.

Create a transit gateway. Set up an AWS Direct Connect gateway and one Direct Connect connection between the remote office and the Direct Connect gateway. Associate the transit gateway with the Direct Connect gateway. Configure a separate private virtual interface (VIF) for each VPC, and configure routing.